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The evolution of incretin-based pharmacotherapy, from liraglutide to tirzepatide, demonstrates how understanding intestinal hormonal mechanisms can transform chronic disease care (MACDONALD et al., 2022)
Research on obesity and sexual function provides relevant context
GLP-1 receptor agonists and GLP-1 and glucose-dependent insulinotropic peptide agonists have several mechanisms of action, including reduction of gastric emptying, inhibition of glucagon secretion, beneficial changes in the intestinal microbiome, and direct effects on hypothalamic nuclei to enhance satiety (which promotes weight loss)
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When it activates, it slows how fast your stomach empties and turns down hunger signals
