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O campo se beneficiaria de replicao independente de achados gastrointestinais-chave, caracterizao formal de dose-resposta incluindo doses acima e abaixo da faixa padro, estudos de segurana de longo prazo avaliando especificamente efeitos do trato gastrointestinal durante administrao crnica, e ensaios controlados randomizados em condies gastrointestinais humanas com tamanhos de amostra adequados e endpoints pr-registrados

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