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However, important considerations regarding thyroid medication interactions, dose adjustments during weight loss, and specific safety monitoring warrant careful medical evaluation before initiating treatment

Research backs this up: when using GLP-1s to aid in weight loss, they were found to effectively reduce BMI, triglycerides, waist circumference, and total testosterone in people with PCOS, according to a 2024 meta-analysis in the Journal of Diabetes and its Complications

In the semaglutide vs retatrutide comparison specifically, participants receiving retatrutide had not yet reached a weight plateau, suggesting additional efficacy beyond what was measured at trial end

At this point, the focus shifts from active weight loss to weight maintenance, which the medication continues to support through appetite suppression and metabolic effects

We require a mandatory 7-day washout period before you transition from one medication to another