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S2c, d) Dual blockade of GDF8 and ActA during GLP-1 RA-treatment of obese, cynomolgus monkeys preserves/increases lean mass, while also increasing fat loss To determine whether the above findings in obese mice would translate to obese primates, we performed a 20-week study in obese cynomolgus monkeys fed a high-fat, high-fructose diet
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Both peptides bind to the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a) on pituitary somatotropes, triggering pulsatile GH release
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