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This is felt to be due to the detoxification effect of B12 in patients who have methylation issues

GHK-Cu is a naturally occurring copper peptide found in the human body that plays a critical role in: Collagen and elastin production Skin renewal and repair Wound healing and tissue regeneration As we age, natural GHK-Cu levels decline, which contributes to wrinkles, loss of firmness, slower healing, and skin damage

Zechmann B, Mauch F, Sticher L, Mller M (2008a) Subcellular immunocytochemical analysis detects the highest concentrations of glutathione in mitochondria and not in plastids

B12 and B-complex options are common for energy and focus