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Current NICE guidance treats obesity as a chronic condition and recommends treatment for at least 12 months, with potential continuation if it remains safe and effective

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Tirzepatide generally produces greater average weight loss than semaglutide and is often better tolerated, although both medications have similar gastrointestinal side-effect profiles

Body composition (fat loss, muscle tone), athletic recovery CJC-1295 without DAC generally outperforms sermorelin on visible body-composition changes over 23 months, because the larger GH pulse drives more IGF-1 elevation

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