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Additional Phase 3 readouts expected in 2026

Fabry Disease Fabry disease is a genetic disorder caused by a deficiency in lysosomal -galactosidase A, of which neuropathic pain is the hallmark

The deacetylation of SHMT2 at K95 by SIRT3 (Wei et al., 2018) or desuccinylation at K280 by SIRT5 (Yang et al., 2018) has been shown to enhance the enzymatic activity of this protein, and the deacetylation by SIRT3 also has been shown to stabilize SHMT2 through avoiding its autophagic degradation (Wei et al., 2018)

Role of Metabolic H2O2 Generation: REDOX SIGNALING AND OXIDATIVE STRESS

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission