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Key Takeaway: Tirzepatide targets two metabolic receptors (GLP-1/GIP) to offer up to 20.9% average weight loss, while Retatrutide attacks fat storage via three pathways (GLP-1/GIP/Glucagon), yielding unprecedented weight loss averages near 24.2% in Phase 2 trials
A1C reduction of 1.7-2.0% across doses at 40 weeks
Bikman argues that this explanation misses the bigger metabolic picture.He begins by reviewing the incretin effect, where oral glucose produces a stronger insulin response than the same glucose given intravenously because the gut releases hormones such as GLP-1 and GIP
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Morbid obesity : Cap the dose at 100 kg body weight
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