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Why GLP-1s Are Revolutionary: Historical Context: Before GLP-1 medications: Weight loss medications produced 3-7% average weight loss Only bariatric surgery achieved 15-30% weight loss Many people couldnt access surgery due to cost, risk, or preferences Gap existed between ineffective pills and invasive surgery GLP-1s filled this gap: Producing 10-22% weight loss with medication alone Non-surgical option with bariatric-level results Relatively few contraindications Once-weekly administration Generally well-tolerated How GLP-1 Medications Work: Natural Hormone Mimicry: GLP-1 is a hormone your body naturally produces in your intestines after eating

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Review the connection between melanocortin signaling, circadian rhythm, drowsiness effects, and what users actually experience

These peptides are being explored for their role in supporting biological processes involved in tissue repair, inflammatory balance, and skin and gut health

Progress in neuro-psychopharmacology & biological psychiatry