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ACS Chem Neurosic 10 (2), 777782

VO2 Max: The Gold Standard Longevity Biomarker If you want to predict how long someone will live, measure their VO2 max

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Before combining medications, discuss optimizing your current therapy by ensuring adequate dosing and treatment duration, exploring FDA-approved alternatives like tirzepatide or phentermine-topiramate ER, intensifying lifestyle interventions with behavioral therapy, or considering metabolic surgery if you meet clinical criteria