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High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

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SMAD7 functions as an inhibitory SMAD that competes with R-SMADs for receptor binding, thereby negatively regulating the pathway [40]

We generated 3D spheroids using simulated microgravity in the rotary cell culture system (RCCS) developed by NASA and have used these as tissue models for testing the effects of radiotherapy (RT) in combination with epigenetic therapy (ET) and radioimmunotherapy (RIT), among several other promising modalities for brain cancers, especially glioblastoma, which currently lacks effective treatment