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Current investigations explore relationships between NNMT inhibition and: Obesity research Healthy aging Cellular metabolism Mitochondrial biology Energy homeostasis Fat metabolism Glucose regulation Nutrient utilization Researchers also investigate whether NNMT inhibition influences broader biological pathways connected with longevity research and metabolic resilience
This approach, originally proposed by Professor Ernest Starling in the early 1900s, initially focused on gut hormones but was overshadowed by discoveries in insulin and leptin [14]
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