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Above all, as with all MR studies, pleiotropy effects in the MR setting are challenging ( 5 Conclusion In conclusion, we provided evidence that genetically proxied GLP-1RAs were associated with a reduced risk of ED, and to a lesser extent, T2D, obesity, hypertension and CVD mediated this effect

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"Discontinuation of GLP-1 receptor agonists leads to significant increases in HbA1c and fasting glucose levels", notes Dr