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The exposure of evolocumab decreased with increasing body weight

In part, this risk relates back to one of the main benefits of GLP-1s: rapid weight loss

(Source) Intestinal obstructions: One study found that participants who took an incretin-based drug (e.g, a GLP-1 like Ozempic) were over 4.5 times more likely to report having an intestinal obstruction than those taking other diabetes medications

Start with basic movements, focus on consistency, and consult a healthcare provider before beginning any new exercise regimen