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Photoprotective DNA Repair Signaling Research demonstrates that MC1R activation by -MSH analogues including MT-1 upregulates nucleotide excision repair (NER) capacity in melanocytes, reducing UV-induced cyclobutane pyrimidine dimer (CPD) accumulation independently of melanin pigmentation (Kadekaro et al., Cancer Research, 2005)
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UK risk stratification uses the FIB-4 score: low risk is 2.67 at any age
However, further validation through larger randomized controlled trials and a more extensive body of research is necessary
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