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Prescribing an unapproved new drug outside a trial is technically illegal under the FDCA (aside from narrow compassionate-use exceptions)
The use of DPP-4is as a comparator provided a highly comparable control group, particularly as both drugs were used in the setting of sole add-on medication to metformin, and both drugs have similar priority in the management of T2D
Translocase of outer mitochondrial membrane 7 activation enhanced mitophagy mediated by PINK1/Parkin within TECs to attenuate kidney injury in diabetic mice (150)
Xie N, Tan Z, Banerjee S, Cui H, Ge J, Liu RM, et al
10.1128/MCB.22.13.4943-4951.2002 37 FerroM.BrugiereS.SalviD.Seigneurin-BernyD.CourtM.MoyetL.et al
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