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Some GLP-1 drugs, particularly liraglutide, have been linked to reduced digoxin levels, so your doctor may monitor serum levels more closely, especially if you have kidney issues

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Researchers hypothesized that, while the increased thyroid hormone increased carnitine synthesis, it also accelerated mitochondrial fatty acid oxidation (similar to what was seen to happen in a hyperthyroid state), which reduced carnitine levels

Semaglutide should not be used by people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2