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In mice, voluntary physical exercise is associated with an increase in hippocampal neurogenesis [162,163,164] and with enhancement of cognitive functions [165,166,167]

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In parallel, levels of the PPAR agonist 15-deoxy-12,14-prostaglandin J2 (15d-PGJ2) increased by approximately 40% at week 36 with both higher-dose regimens

10.1254/jphs.fp0061322 29 DrmicD.SamaraM.VidovicT.MalekinusicD.AntunovicM.VrdoljakB.et al (2018)