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A recent screening-based study has identified several promising SARM1 inhibitors, including non-competitive inhibitors such as berberine chloride and zinc chloride 233 , suggesting the presence of an allosteric binding pocket that can be targeted for therapeutic development
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(2) inhibition of microglial M1 polarization and NLRP3 inflammasome activation, leading to a reduction in pro-inflammatory factors such as IL-1 and TNF-
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