Statins inhibit coenzyme Q10 synthesis, which can impair electron transport chain function and increase mitochondrial oxidative stress in skeletal muscle, leading to statin-associated myopathy
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While the theoretical rationale is sound, no clinical trial has tested this specific combination, and the safety profile of triple-pathway activation through separate compounds is unknown
Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer
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