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doi: 10.3389/fphar.2024.1415879 Received 11 April 2024 Accepted 20 August 2024 Published 07 October 2024 Volume 15 - 2024 Edited by Nuria Lloberas, Bellvitge University Hospital, Spain Reviewed by Shao-Yu Yang, National Taiwan University Hospital, Taiwan David Arroyo, Gregorio Maran Hospital, Spain Maria Marques, Puerta de Hierro University Hospital Majadahonda, Spain Updates Copyright 2024 Martos-Guillami, Vergara, Llorens-Cebri, Motto, Martnez-Daz, Gonalves, Garcias-Ramis, Allo-Urzainqui, Narvez, Bermejo, Muoz, Len-Romn, Ferrer-Costa, Jacobs-Cach, Vilardell-Vil and Soler
The 3,5-dimethyl-4-fluoro-phenyl ring interacts with residues in TM1 and TM7, bridging these two helices and stabilizing their relative orientation
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It is safe for short-term use on injection sites and provides noticeable relief within hours of application
