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It started because, anecdotally, physicians were starting to see that their patients were reporting, Oh, I havent smoked in a while, and Oh, I havent had alcohol in a while. The results spurred case reports, which led to preclinical studies and mouse models with often promising results
Clinicians should monitor serum ammonia if unexplained cognitive decline, lethargy, or vomiting occurs during dual therapy and promptly discontinue one agent
322 Likewise, blocking mitophagy through agents such as chloroquine compromises mitochondrial function, enhancing the efficacy of targeted therapies and preventing relapse 321,322 Recognizing the inherent heterogeneity and adaptability of plastic tumor cells, combination therapies are increasingly emphasized to achieve durable responses
Choline: Supports fat transport and liver function while helping maintain cellular integrity and brain health