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Ferner came to this conclusion after reviewing several experimental and clinical observations

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doi: 10.1080/13693780701651681 54 NaganawaRIwataNIshikawaKFukudaHFujinoTSuzukiA

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DPP4 needs dimerization for enzymatic activity, and this is the predominant form of DPP4 ( The serine in the active site of DPP4 is located in the sequence GlyTrpSerTyrGly and is part of the catalytic triad (Ser 630, Asp 708, His 740) within the catalytic region of DPP4