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A follow-up analysis, 17 weeks after stopping treatment, found modest gains in weight and A1c levels, bringing some patients back into the prediabetes and diabetes ranges, and underscoring the likely need for chronic treatment
The Precision Peptide Test also analyzes FTO rs9939609, MC4R rs17782313, and GIPR rs1800437 variants that influence hunger signals, energy expenditure, and glucose control
Therefore, the combined use of GLP-1 RAs with therapies targeting intrahepatic pathways, such as thyroid hormone receptor (THR-) agonists, fibroblast growth factor-21 (FGF21) analogues, and peroxisome proliferator-activated receptor (PPAR) agonists, presents a promising approach for MASH treatment
For patients who experience a sustained increase in resting heart rate while taking semaglutide, the drug should be discontinued
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