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Permanent damage is unlikely unless you have overdosed, chronic use with liver compromise, or severe malnutrition

Lancet 403, 183202

Know When to Seek Help While constipation is a common side effect, its essential to recognize when it might signal a more serious issue

2014 Jan;171(1):186-201.

The authors reported that Long-R3-IGF-I disappeared rapidly from circulation after 4 hours following intramuscular administration in rats, while the related analogs Des(13)-IGF-I and R3-IGF-I remained detectable for up to 24 hours [3]