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63% of participants on the 15mg dose achieved at least 20% weight loss, compared to 1.3% on placebo
Any weight loss associated with yerba mate is likely attributable to increased calorie expenditure and appetite suppression via central nervous system stimulation, not hormonal GLP-1 pathways
Adding or increasing resistance training helps preserve muscle mass, which maintains metabolic rate
The researchers point out that GLP-1RAs are expensive and can potentially widen health disparities as obesity disproportionately affects marginalized racial, ethnic and socioeconomic communities
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