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Someone splitting their weekly dose into twice-weekly injections, for example, can use a plotter to see how that changes their peak and trough pattern compared to a single weekly shot
Some lifestyle habits may also help keep you more regular while taking this medication
A recent pooled analysis integrating data from these withdrawal trials (n=800) reported a mean absolute weight regain of 9.69 kg after discontinuation of semaglutide or tirzepatide [118], underscoring the chronic and relapsing nature of obesity that necessitates long-term pharmacologic management
So the weight gain reflects a biological shift, which is why the same diet and exercise that worked before often stop working and a different strategy is needed
As Figure 4C shows, for further comparison, we took the intersection between them
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