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Bibcode:1992PNAS...89.8641T
In a study conducted by Bertram et al
Patio-Cardona, S., Garrido-Miguel, M., Pascual-Morena, C., Berlanga-Macas, C., Lucern-Lucas-Torres, M., Alfaro-Gonzlez, S., & Martnez-Garca, I
Further, active forms of GLP-1, as well as inactive metabolites, are rapidly eliminated by the kidneys ( The short half-life of endogenous GLP-1 has led to the development of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors as therapeutic strategies to extend the duration of GLP-1 action in the treatment of type 2 diabetes ( GLP-1 receptor agonists The first approved GLP-1 receptor agonist (GLP-1 RA) was exenatide in the United States of America (USA) in 2005 and in Europe one year later