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The latest results follow positive Phase III data from TRIUMPH-1 and TRIUMPH-4 , which evaluated retatrutide in other obesity populations and complications
Thorens B
Fan Y, Yu Y
However, synaptic plasticity and memory formation are impaired in GLP-1 receptor knockout mice (118)
Moreover, T4 has a narrow therapeutic window, where both excessive and insufficient doses can result in suboptimal therapeutic outcomes or adverse effects, further complicating its clinical application (70)
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