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Many angiogenic factors, such as VEGF-A, HGF, transforming growth factor (TGF) and epidermal growth factor (EGF) (Folkman, 2003), demonstrated elevated expression levels in HCC tumors (Mas et al., 2007), Moreover, these factors induce angiogenesis through a number of mechanisms, one of them is via the HGF/c-Met signaling pathway

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HUBERMAN: Just as there are anti-cancer drugs that focus on the VEGF pathway to try and discourage vascularization of tumors, there are drugs that discourage the release of growth hormone to discourage the growth of tumors

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