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Indeed, an important issue for the potential cognitive and mental health effects of GLP-1RAs, which our analysis cannot fully address, is whether these medications provide symptomatic relief only via their well-established cardiometabolic benefits, or by directly targeting physiopathological mechanisms behind cognitive and mental symptoms
Furthermore, we did not use operationalized criteria (for example, Diagnostic and Statistical Manual 5th edition) to define the populations of interest because these would not be applicable across animal and human studies, but instead relied on the definitions provided by the individual articles
The relevance of this detoxification pathway extends significantly to the vulnerable preterm infant population
By precisely targeting Hv1 in microglia, the nanoparticles effectively suppressed microglia-induced neuroinflammation, minimizing off-target effects
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