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Aggregation creates potentially harmful clumps Perhaps the most concerning degradation pathway for expired tirzepatide is aggregation
Assessing the requirement of CD36 for GLP-2-mediated increases in intestinal-TG secretion are complicated by the increased fatty acid absorption (as shown by appearance of radiolabel in plasma), TRL-TG and TRL-apoB48 secreted by Cd36 / mice compared to wild-type controls (Hsieh et al., 2009)
Trillenberg P, Sprenger A, Machner B
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2020;22(Suppl 1):4654
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