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Conclusion SGLT-2 inhibitors and GLP-1 receptor agonists reduce the risk of major cardiovascular events, heart failure, and stroke in type 2 diabetes patients, regardless of metformin use
If fatigue is your bigger issue, the TrimRx article on GLP-1-related tiredness may be useful
Injection site reactions, including pain, redness, itching, and swelling at the injection point, occur in some patients
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