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Special populations: dosing adjustments for age, kidney function, and prior bariatric surgery Age over 65: The STEP-1 trial included 12% of patients over age 65

Zheng Z, Zhao K, Yang S

Pharmacokinetic Highlights CJC-1295 exhibits a terminal half-life of approximately 135 h in humans, attributed to reversible albumin conjugation via MPA

Some of the more common side effects in clinical trials compared to placebo include: Gastrointestinal side effects such as nausea, vomiting, constipation, or diarrhea Abdominal pain Headache, dizziness Fatigue Dyspepsia, abdominal distension, eructation Hypoglycemia (low blood sugar) in patients with type 2 diabetes Flatulence, gastroenteritis, and gastroesophageal reflux disease (heartburn) Hypoglycemia (low blood sugar levels), a more serious side effect of GLP-1 drugs, may also occur

Half-life: ~2 hours