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Gallstone risk is a known class-level signal with rapid weight loss
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Butera et al
Inhibition of MEK1/2 increases AKT phosphorylation To test whether MEK inhibition can increase AKT phosphorylation to activate AKT, we knocked down MEK1 and MEK2 expressions with mek1 and mek2 siRNA, respectively
Rather than targeting IGF-IR/InsR themselves, an alternative strategy would be inhibition of the master regulators of RTKs or downstream signaling hubs such as IRS1/2 [205,206,207,208]
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