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Among the mutations considered, Glu113Lys enhanced catalytic performance and was added to X(GD_L)dX(GD_L)f to yield X(GD_L)gX(GD_L)i
There is a similar beneficial effect in the rats with the Pringle maneuver, ischemia, reperfusion, and suprahepatic inferior caval vein occlusion (BuddChiari syndrome) (Kolovrat et al., 2020)
A Simple Rotation Strategy: Don't overcomplicate it
It is clear that comparative in vivo metabolism and toxicity studies need to be undertaken with AMAP in species other than hamster and mouse, most notably in the rat
Mitochondria-targeted antioxidants protect Friedreich ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
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