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PT-141, measured in a single radioligand displacement series against I-NDP-alpha-MSH on membranes from BHK570 cells stably expressing each human subtype, returned Ki 0.25 nM at MC4R, 6.4 nM at MC1R, 17 nM at MC5R and 53 nM at MC3R, roughly 26-fold, 68-fold and 210-fold preference for MC4R over MC1R, MC5R and MC3R respectively
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Plants have evolved specific strategies too in order to neutralize potentially harmful compounds such as xenobiotics and heavy metals
10.1016/j.peptides.2016.02.007 154
Telomeres are repetitive DNA sequences (TTAGGG/AATCCC) that cap the ends of chromosomes, protecting genetic material during cell division
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