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The following data were collected: publication year, country and continent, study setting (e.g., hospital, private practice, academic clinic), sample size, age range, mean age, study design, population characteristics, intervention details, outcomes, and effect measures (e.g., serum B12 levels)

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Hypoglycemia is a real risk at doses above 60 mcg, particularly when combined with insulin or during caloric restriction

KLOW thus additionally covers inflammation modulation