Protecting muscle mass with oral GLP-1s A major concern with the rapid weight loss seen with GLP-1 therapy is that the body doesnt just lose fat, the weight loss also affects muscle as well
Semaglutide acts on one hormone pathway
Weekly dosing is the standard evidence-based schedule
This phenomenon is associated with uncoupled mitochondrial respiration, elevated proton leak, ROS formation, cellular apoptosis, and, more important, increased myocardial oxygen consumption (56)
Because GLP-1 receptor agonists directly influence pancreatic function, theoretical questions have been raised about whether chronic stimulation of these receptors might contribute to pancreatic pathology, although there is no evidence confirming this mechanism