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5AM-1MQ OVERVIEW Category: Small Molecule / Selective Enzyme Inhibitor (NNMTi) How It Works: Selectively inhibits the Nicotinamide N-methyltransferase (NNMT) enzyme to increase cellular NAD+ levels and metabolic expenditure
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The Kraus 2014 Nature Paper: Why Adipose Research Specifically The 2014 Nature paper by Kraus and colleagues (titled "Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity") established the adipose-NNMT connection that anchors all subsequent NNMT-inhibition research in fat biology
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