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Abnormal iron metabolism is a significant trigger for ferroptosis, with iron-related proteins including transferrin receptor protein 1 (TfR1), ferritin (FTH and FTL), and iron export proteins playing essential roles in iron homeostasis
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However, no apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity
The trials included both single-dose pharmacokinetic studies and long-term treatment protocols extending up to 24 weeks
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