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Cells were treated with 0 or 10 mmol/L of PhS for 24 hours and then treated with hydrogen peroxide (0, 10, 20 mol/L) for 5 hours in the absence or presence of reduced glutathione (0, 0.05, 0.1, 0.2, 0.5 mmol/L)

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These findings indicate that the lead compounds can successfully penetrate tissue-like environments to target TBC1D15 and upregulate Rab7-dependent cholesterol transport pathways

Radomski MW, Palmer RM, Moncada S