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Topical prescription agents such as hydroquinone, retinoids, azelaic acid, or tranexamic acid are applied directly to affected areas and are used under medical supervision to influence pigment production and skin renewal processes
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Canakinumab is a humanized monoclonal antibody that targets interleukin 1- (IL-1), and thus potentially could be useful in mitigating some of the inflammation in SCD
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Higher GBB levels were also associated with increased risk ofand poorer survival frommajor cardiovascular events (death, myocardial infarction, or stroke), but only when TMAO levels were also elevated.14 Continuing along the carnitine metabolism pathway to the liver, individual genetic variation may play a role in elevated TMAO levels by increasing conversion of TMA to TMAO by the enzyme flavin-containing monooxygenase 3 (FMO3)
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