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If your gut lining becomes leaky, toxins from bacteria can enter your bloodstream, triggering inflammation that makes it even harder for insulin and GLP-1 to do their jobs

[5] Impairment of either fatty acid metabolism or glycogen metabolism leads to decreased ATP (energy) production

Ghosh A, Michalon A, Lindemann L, Fontoura P, Santarelli L (2013) Drug discovery for autism spectrum disorder: challenges and opportunities

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When pancreas compensates by secreting more insulin, fat accumulates (especially visceral fat), inflammation rises, and the body begins to defend this altered metabolic set-point as its new normal