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Interestingly, whole-body, or CNS-specific, GLP-1R knockout in a mouse did not result in sizable change in body weight, fat mass or hyperphagia
In chronic kidney disease, the pivotal FLOW trial demonstrated that semaglutide 1 mg reduced the risk of major kidney events by 24% in patients with type 2 diabetes and CKD, resulting in a dedicated indication in this population
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GLP-1s and Colonoscopy Prep Recent research has shown that GLP-1 drugs may affect colonoscopy effectiveness, especially when it comes to bowel prep and the quality of how well a GI can see your colon during the colonoscopy
As a class, the DPP-4 inhibitors are weight neutral, causing neither weight gain nor weight loss
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