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While one potential side effect of pioglitazone is weight gain, DeFronzo said that rather than being a negative association, this shows the drug is working to mobilize fat to less harmful areas of the body

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MSM does not require methylation for processing, so its typically well-tolerated by individuals with MTHFR mutations

The study was conducted in accordance with the ethical standards outlined in the Declaration of Helsinki and was approved by the institutional review board