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That growth hormone then acts on the liver and peripheral tissues to boost insulin-like growth factor-1 (IGF-1) production

The sensation in your chest is real

The Numbers Behind Blood Pressure Reduction When researchers combine results from many studies, they find that GLP-1 medications lower systolic blood pressure (the top number) by: 2 to 6 mmHg on average when compared to placebo Semaglutide: about 3 to 5 mmHg reduction Liraglutide: about 2.5 to 3 mmHg reduction Tirzepatide: about 7 to 11 mmHg reduction (the most powerful) These numbers might seem small, but they matter

Reduced appetite is the intended effect, but sometimes it feels too extreme

Avoid direct sunlight