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Recent multisociety practice guidelines have offered more clarity for clinicians who provide sedation outside the operating roomincluding dentists, endoscopists, and proceduralistswhen treating patients on GLP-1 receptor agonists (GLP-1 RAs) like Semaglutide, Ozempic, or Wegovy.sciencedirect Key Recommendations: Shared Decision-Making: Management should involve the patient and all relevant care teams (procedural, anesthesia, prescribing), considering metabolic needs and individual risk factors
Side effects, primarily gastrointestinal, are manageable with proper titration
Reviews, editorials, animal studies, and studies based solely on spontaneous pharmacovigilance reports were excluded when pooling data for scientific analyses
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So when Stephen Bloom's paper came out in January of 1996, and he was the first one to call GLP-1 a neurotransmitter, I think, but I was already way into actually screening these kind of molecules that later then became liraglutide
