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Only thymosin beta-4, the parent molecule of TB-500, has robust human values with a terminal half-life of about 0.5 to 2.08 hours Wang et al., 2021
Compartment syndrome can develop at injection sites in leg muscles, causing numbness, blood clots and muscle spasms that result in permanent loss of function
But with a 2mg/mL concentration (5mL of water added), that same 4mg dose requires 2.0mL of liquid, which is an entire insulin syringe worth and creates a large, uncomfortable injection volume
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2010;16(3):BR8188
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