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Stuebe AM, Meltzer-Brody S, Pearson B, Pedersen C, Grewen K
The mechanism of action involves binding to GLP-1 receptors in the brain, particularly in areas that control appetite and food intake
GLP-1 Dosing and Titration for Obesity and Weight Loss Wegovy Start: 0.25 mg weekly, titrate every 4 weeks to 1.7 mg or 2.4 mg For MASH: 2.4 mg weekly is the recommended dose
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Thus, cotadutide, via direct hepatic (GcgR) and extrahepatic (Glp-1R) effects, exerts multifactorial improvement in liver function and is a promising therapeutic option for the treatment of steatohepatitis
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